can glp 1 cause acid reflux GLP-1 Heartburn: Management on Semaglutide Gastrointestinal effects of GLP-1 receptor

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Zhang H, Liu H, Zhou L, Yuen J, Forman HJ

As a public health proposition, this new class of weight-loss drugs is a positive development, but for those who may think that an injection, and now a pill, is a silver bullet that eliminates the need for lifestyle modifications like diet and exercise, think again

Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues