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It functions by targeting two key hormones involved in insulin secretion: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

Serious adverse effects requiring immediate medical attention include signs of pancreatitis (severe abdominal pain radiating to the back), gallbladder disease (right upper quadrant pain, particularly after meals), acute kidney injury (decreased urine output, swelling), or severe allergic reactions

20.2% vs 13.7% over 72 weeks

NAION is rare in the general population somewhere between 2.5 and 11.8 per 100,000 people annually

MOTS-c is one of the several mitochondrial-derived peptides, including humanin and the SHLP family of peptides