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In addition, prolonged exposure to pharmacologic doses of long-acting GLP-1 RAs induces tachyphylaxis for the effects on gastric emptying, and that is why nausea vanishes quickly after the beginning of treatment in most patients [19]

In human plasma, the GHK concentration is approximately 200 ng/mL at the age of 20, but declines to around 80 ng/mL by the age of 60

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2001 Oct;23(7):780-4