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CCAS can also be seen in complex cerebrocerebellar pathological conditions, such as cerebellar and brainstem hemorrhage, complex cerebrocerebellar degeneration with gene variants (senataxin, gene, and X-linked recessive ATP2B3 gene), pontine cavernous malformation, ataxia with oculomotor apraxia type 2 (AOA2), Friedreichs ataxia, SCA1, SCA2, SCA3, SCA7, SCA17, and multiple system atrophy of the cerebellar type (MSA-C) [9]

SOD1 overexpression alters ROS production and reduces neurotoxic inflammatory signaling in microglial cells

Due to the limited data, it should be avoided by anyone who is pregnant, breastfeeding, or undergoing active cancer treatment

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More recently, kava has received widespread attention for its relaxing and stress-reducing properties