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NAION typically causes sudden, painless vision loss in one eye and may also produce blind spots, reduced peripheral vision, diminished color perception, or permanent visual impairment

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This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult

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doi: 10.1002/tox.20609 179 RasheedA.LiH.TahirM