However, systemically injected labeled GLP1RAs show limited brain penetration, with the strongest labeling observed in circumventricular organs such as the AP and arcuate nucleus (ARC), suggesting that most central effects are mediated by downstream signaling from these primary GLP1RA binding sites 14
Importantly, it is often those who are better resourced, whether in terms of cultural capital or functional capabilities (eg, the capacity to speak and self-advocate), who can navigate the medical system to ensure milder diagnoses receive supports
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