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This suggests that HIF-1 may promote angiogenesis in response to hypoxia by up-regulating the expression of genes such as VEGF

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In addition, alcohol is metabolized by alcohol dehydrogenase and cytochrome P450-2E1 (ADH and CYP2E1) enzymes found in the brain endothelial cells leading to the production of ROS, which is responsible for oxidative stress and production of neurodegenerative agents (2)

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