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In: UpToDate , Basow, DS (Ed), UpToDate, Waltham, MA
Multiple studies confirm the mechanism in both cell culture and animal models
Additionally, natural compounds [e.g., icariin II (234) and lycorine (241)] lack clear molecular targets: their direct binding partners or upstream signaling pathways (e.g., epigenetic regulators and kinase cascades) that modulate ferroptosis are poorly defined, hindering the optimization of potency and selectivity
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