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Endothelin antagonists for diabetic and non-diabetic chronic kidney disease

All reagents and solvents were obtained from commercial sources except for the protected pentafluorophenyl esters: Z-Trp-OPfp, Z-D-Phe-OPfp, Z-His( T Boc)-OPfp, Z-Lys( Boc)-NH2, and Z-Asp(O t Bu)OPfp, which were prepared in-house according to the well established procedures [31,32]

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