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Research has documented effects on approximately 4,000 genes, with 59% being upregulated (turned up) and 41% being downregulated (turned down)

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(Peptide Gurus) By mimicking the part of FOXO4 that binds p53, FOXO4-DRI competes for that interaction, frees p53, causes its nuclear exclusion and triggers apoptosis in the senescent cell, thereby selectively reducing senescent cell burden