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This suggests that lifestyle-associated modulation of nuclease activity could represent a complementary, non-pharmacological means of promoting NETs clearance, particularly in chronic inflammatory states [264]

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Patient education : Understanding the condition, setting realistic expectations, and learning self-management techniques are crucial for long-term outcomes

They do this by: reducing appetite and food reward lowering carbohydrate load slowing gastric emptying so glucose enters the bloodstream more gradually smoothing post-meal glucose rises lowering baseline glucose and insulin exposure over time As chronic insulin exposure falls, the pressure driving ectopic fat storage eases