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Like a furnace uses fuel to generate heat, mitochondria use nutrients to generate energy

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237 The therapeutic effects of the amino salicylic acid class drug sulfalazine, 238 the antibiotics azithromycin and buspirone, 239 the opioid agonist human opiorphin, 240 the PDE5 inhibitor sildenafil 241 and many other commonly used clinical drugs in UC are attributed to the inhibition of the NFB pathway, which inhibits the expression of inflammatory cytokines and the infiltration of inflammatory cells, alleviating intestinal epithelial damage

doi: 10.1186/s13075-018-1600-5 31 ShenXWangCLiangNLiuZLiXZhuZJet al

This should include: TSH Free T4 and free T3 Reverse T3 Thyroid peroxidase (TPO) antibodies (to assess for autoimmune Hashimotos thyroid disease) Iron, ferritin, vitamin B12, vitamin D, and selenium levels Thyroid dysfunction frequently co-occurs with metabolic diseases such as type 2 diabetes and obesity, and optimizing thyroid status is crucial for overall metabolic health