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Traditional obesity intervention strategies (e.g., dietary control, exercise, conventional weightloss drugs) are often limited by slow onset, obvious side effects, and high rebound rates, and can hardly fundamentally reverse the abnormal metabolic phenotype of adipose tissue

For individuals receiving B12 injections for severe deficiency, there have been isolated reports of hypokalaemia (low potassium) during initial treatment, as rapid cell production consumes potassium

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In addition, NO reacts with superoxide (O 2 ), a major ROS, to produce peroxynitrite (ONOO), a potent oxidant that damages cellular components such as proteins, lipids, and DNA [136138]