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This fundamental difference introduces a degree of uncertainty that is incompatible with safe medical care

Hujanen ES, Seppa ST, Virtanen K

Sources Unlike plants and most animals, humans have lost the ability to synthesize vitamin C endogenously and therefore have an essential dietary requirement for this vitamin (see The Recommended Dietary Allowance)

The same trials are also the only window onto long-term safety: what are the implications of the elevated resting heart-rate in patients with heart failure or irregular heartbeats, let alone healthy individuals considering the longer term health implications of these drugs

It is metabolically destructive