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The FAO medium was Krebs-Henseleit buffer supplemented with 0.5 mM L-carnitine and 50 mM HEPES.Under this protocol, basal OCR for healthy cells was approximately 100200 pmol O 2 /min, and the CPT1B inhibitor etomoxir (40 M) was used to distinguish exogenous from endogenous fatty-acid oxidation

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This transporter has similarities to the cystic fibrosis transmembrane conductance regulator (CFTR), which has been shown to be responsible for GSH flux from lung airway epithelial cells (Kogan et al , 2003), suggesting that ABC transporters might function in the transport of glutathione in mammalian cells

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