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Glutathione-ascorbate cycle The ascorbate-glutathione cycle , sometimes Foyer-Halliwell-Asada pathway , is a metabolic pathway that detoxifies hydrogen peroxide (H 2 O 2 ), a reactive oxygen species that is produced as a waste product in metabolism

Physiol Rev 98:11691203 Yang M, Vousden KH (2016) Serine and one-carbon metabolism in cancer

The reason astrocytes are used as therapeutic targets is that neurons cannot survive independently from astrocytes (Bylicky et al., 2018)

For example, prostate cancer and B-cell lymphomas promote FAO as the main source of energy production and express FAO enzymes at high levels, even under nutrient-replete conditions 10,11

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