Kaplan GG, Hubbard J, et al
3 Reactive fibroblasts, the presumptive source of matrix production, are intimately admixed with the tumor cells, although there is some controversy about the source of stromal collagenization in these neoplasms
doi: 10.1039/D1FO00209K 60 ZhaoY.ZhangC
In ageing, mitochondria start to dysfunction due to the decline in de novo glutathione synthesis, resulting in enhanced oxidative stress, thereby making cells susceptible to microbial in- fection and death
The advent of personalized and engineered probiotics introduces further complexity, as factors such as individual microbiome variability, host genetics, and polypharmacy can influence both the efficacy and safety profiles, thereby complicating standardized evaluation (527, 528)