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A comprehensive evaluation of various factors, including the dosage of the medication, the administration route, the specific type of hormonal agent utilized (whether combined estrogen or progestin), the timing of treatment initiation, the patients age, her cardiovascular disease history, and the thromboembolic characteristics associated with estrogen and progestin, is essential for postmenopausal hormone replacement therapy (171)

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Repeated injection at the same location causes lipohypertrophy, a condition where the subcutaneous tissue thickens and hardens into lumps