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In another study evaluating the potential of Pinoresinol-4- O --d-glucopyranoside (Pgu) using the lithium/pilocarpine-induced rat model, seizure induction caused an increase in the levels of malondialdehyde (MDA) a marker of oxidative lipid damageand decreased catalase activity, while also increasing the expression levels of PTGS2, all of which was reversed by Pgu pretreatment, which also mitigated neurodegeneration 47

Rockville, MD: United States Pharmacopeial Convention