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In animal studies, it affects angiogenesis (blood vessel formation), collagen organization, and growth factor modulation through pathways including EGR-1 gene upregulation

Canfosfamide (TLK286) is a pro-drug that exploits the activity of GSTP to release a part of it as a DNA-binding alkylating agent 28,29

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During treatment, your provider may review your response, tolerability, and whether your plan should continue or be adjusted