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Nearly a third of patients on the higher dose lost 25% or more of their starting weight

The most common side effects reported in the tirzepatide groups were diarrhea and nausea.In patients with type 2 diabetes who had inadequate control of blood sugar levels despite treatment with insulin glargine, adding subcutaneous tirzepatide to titrated insulin glargine led to significant improvements in glycemic control after 40 weeks, along with reductions in body weight

Feb 2019;69(1):77-81

Its safe to leave a vial out at room temperature for a few minutes while preparing to take your injection