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Glutamate levels literally decide whether a neuron or connections survives or dies: To support this, studies indicate that the blockade of NMDAR function leads to neuronal apoptosis and degeneration Apoptosis is cell-programmed death

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A population-based study in Sweden showed that infants born small for gestational age had a 3-fold increased risk of developing BO as adults compared with infants of normal birth weight

3 Women are more likely to develop the condition than men, with the average age of onset between 20 and 40 years, although it can commence in adolescence and is thought to be mediated by hormonal factors

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