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However, we found that both Alanine and Cystine substantially fell outside of healthy reference ranges, with Cystine being dramatically reduced in both affected and unaffected siblings with average plasma concentrations of 3.0 mol/L and 3.3 mol/L respectively, while Alanine was found to be elevated regardless of disease status (U:595.5 mol/L, K:589.0 mol/L)

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SUMO was found to be effective in increasing soluble expression of many proteins, including SARS-CoV-2 [38,67], spider dragline silk protein [68], a venom protein JarC [69], apoptin, and a tumor-cell-specific apoptosis inducer [70]