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Cancer cachexia is a serious complication that can cause extreme physical weakness in patients, affecting treatment effectiveness and prognosis

The most common bodys natural response to the medication is a gastrointestinal issue, such as nausea, vomiting, diarrhea, or constipation

Additionally, in patients with type 2 diabetes and advanced chronic kidney disease (estimated glomerular filtration rate 15-30 mL/min/1.73m2), metformin discontinuation was associated with an increased risk of cardiovascular-renal events compared with metformin persistence

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