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This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]
Mechanistically, dulaglutide downregulates matrix metalloproteinases (MMP-3 and MMP-13) and aggrecanases, protecting the articular extracellular matrix [50]
10.3389/fncel.2022.899069 17 CenM.SongL.FuX.GaoX.ZuoQ.WuJ
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