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JA supplementation of alkaline stressed 100 mM Na 2 CO 3 + 10 M JA and 150 mM Na 2 CO 3 + 10 M JA treatments exhibited a 27.65 and 24.05% increase in Gly I activity relative to 100 and 150 mM Na 2 CO 3 treatment levels, respectively, to ensure stress resistance

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This gap is why clinical protocols for acute glutathione repletion -- liver support, immune challenges, detoxification -- consistently use parenteral routes rather than oral supplementation