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Glutamine activates mTORC1 by enhancing glutaminolysis and the production of -KG, which is helpful for the GTP-loading of RagB and lysosomal translocation (Duran et al., 2012)

The medication's gastrointestinal effects may complicate IBD management, particularly in patients with strictures or active disease, so decisions should involve both your gastroenterology and prescribing teams