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Rodent studies Eight preclinical studies investigated the effect of supplementation with a combination of different nutrients on ES-induced behavioral deficits, out of which six studies found an effect of ES on at least one of the behavioral domains investigated and those will be described below

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For patients with heart failure or chronic kidney disease, initiating an SGLT-2 inhibitor first is preferred

1 Introduction DOR is characterized by a reduction in the number and/or quality of oocytes, leading to insufficient ovarian function, sex hormone deficiency, and decreased fertility