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Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, et al

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Therefore, after Fe 2+ is excreted, it is oxidized to Fe 3+ by iron transport auxiliary proteins on the basolateral membrane or by ceruloplasmin, after which the generated pools of Fe 3+ bind with Tf to enter the plasma, forming serum iron, or they are transferred to cells that require iron