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Retrieved 7 November 2025

It is a synthetic analog of human GLP-1, a naturally occurring incretin hormone that plays a central role in glucose homeostasis and appetite regulation

Skipped periods A 2023 research review mentioned that losing 10%--15% of your body weight in a short period of time can cause amenorrhea , the medical term for missed periods

The STEP 1 trial, published in the New England Journal of Medicine, demonstrated 14.9 percent mean body weight reduction with the 2.4mg weekly dose over 68 weeks, compared to just 2.4 percent with placebo

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