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These changes may potentiate the effects of CIT and leucine by improving amino acid uptake, reducing inflammaging, and enhancing NO-dependent vascular responses

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Considering that follicles close to the OE lesion tissues exhibit higher total iron levels and lower oocyte retrieval rates than follicles in healthy ovaries [28], iron overload in the OE may impair oocyte maturation and function by affecting granulosa cells close to the lesion and further mediate the release of abnormal exosomes of granulosa cells

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Torreele, E., Van Der Sluiszen, A