R747W is a mutant phenotype with loss-of-function of the gene encoding iPLA2, which reduces the hydrolytic activity of 15-HpETE-PE, and increases the content of 15-HpETE-PE in cells, and increases the sensitivity to ferroptosis compared with the wild type
That same electron-donating mechanism makes glutathione extremely vulnerable to environmental oxidation: exposure to light, heat, or atmospheric oxygen rapidly converts GSH to its oxidised form GSSG, which cannot perform the same antioxidant function
While previous findings of increased total glutathione in subjects with asthma may reflect an adaptive response whereby synthesis and mobilization of GSH is increased to combat acute insults, these previous findings are more likely due to increased GSSG formation (206) since protein SHs are also reduced in these subjects (15, 236)
The GPX activity seemed to be universal, sensitive and correlated well with heavy metal stress (Kandziora-Ciupa et al., 2013)
C ch hot ng ca Glutathione trong lnh vc m phm lm p Trong lnh vc m phm, Glutathione thu ht s ch ca tt c mi ngi vi t cch l mt cht chng oxy ha mnh m