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This is due to the hydrophobic nature of isoleucine and alanine, which leads to a less soluble peptide that adopts an equilibrium of monomers, trimers and tetramers, whereas A 140 is mostly monomeric (Chang and Chen, 2014)

Inhibition of dipeptidyl peptidase activity by flavonol glycosides of guava (Psidium guajava l.): A key to the beneficial effects of guava in type II diabetes mellitus