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The modification involves replacing the glutamic acid at position 3 with arginine (R3) , and extending the N-terminal region by 13 additional amino acids (MFPAMPLLSLFVN), resulting in a longer peptide chain of 83 amino acids compared to the native 70 in human IGF-1

Supplementary Materials Data Availability Statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s.

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Individuals with low gut microbiota abundance have been found to be susceptible to obesity, insulin resistance and dyslipidemia (le Chatelier et al., 2013)