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These tiny clusters slowly dissolve over the following hours, releasing insulin into the bloodstream at a steady, predictable rate

PubMed Tabbalat RR, Cal NV, Mayigegowda KK, et al

In another study that included a limited population of patients with cirrhosis, the combination of sofosbuvir and ledipasvir achieved SVR12 rates of 97% (without ribavirin) and 100% (with ribavirin) in patients with cirrhosis who were treatment naive after 12 or 24 weeks of therapy.17 However, in a parallel study of patients with cirrhosis who were treatment experienced, SVR12 rates were 100% after 24 weeks of therapy but substantially lower (82%-86%) after 12 weeks, leading to the recommendation that patients with cirrhosis receive 24 weeks of therapy.16 Limitations of this study include the absence of a placebo group to support assessment of treatment-related adverse events

Takano T, Matsumura T, Adachi Y, Terahara K, Moriyama S, Onodera T, et al

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