76 Semaglutide shows mixed BBB evidence, with likely restricted parenchymal entry, but documented preclinical studies of cognitive and neuroimmune benefits attributed to circumventricular access and systemic antiinflammatory effects, 114 , 115 , 116 consistent with emerging data from EVOKE/EVOKE+
N Engl J Med 377:644657 Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS (2019) Dapagliflozin and cardiovascular outcomes in type 2 diabetes
& Wanders, R
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