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One of those circuits handles detoxification

A high titer of RF classifies the patient as having seropositive RA, which is characteristically associated with a more aggressive disease course, greater radiographic joint destruction, and a higher likelihood of extraarticular manifestations, such as the subcutaneous nodule seen on Helen's forearm (Shmerling & Greisen, 2025)

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The cleanest experiment is to discontinue and see if the symptom resolves

This raises ethical questions about the potential risks and benefits of using BPC-157 in humans, especially given the lack of comprehensive human clinical trials