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These residues are absent in the sequences of the other human Na + -independent OCTs and OATs surveyed (Supplementary Fig

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The Data That Changes the Conversation On December 11, 2025, Lilly released topline results from TRIUMPH-4, its Phase III trial of retatrutide in patients with obesity and knee osteoarthritis

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Crucially, the effects of these female-specific mediators on ENOC risk were robust, with BMI, hip circumference, waist circumference, and arm fat mass all showing positive associations following FDR correction (e.g