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Flow cytometry and immunohistochemistry results demonstrated a significant decrease in CD206 + (M2 marker) cell populations and an upregulation of CD86 + (M1 marker), while CD8 + cytotoxic T lymphocyte infiltration into the tumor was markedly enhanced, indicating activation of an adaptive immune response
M1-dominant macrophages overproduce TNF- and IL-6, directly blocking insulin receptor signalling in metabolically active tissues [4]
While preliminary studies and anecdotal evidence are promising, it is still under investigation and not approved for use as a therapy in many countries
Common signs include extreme tiredness, low energy, pins and needles, muscle weakness, disturbed vision, low mood, diffuse hair loss and even premature greying
