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As a -glutamyl cyclotransferase, CHAC1 degrades glutathione, affecting calcium signaling and mitochondrial function

Similar content being viewed by others Introduction Amid the continuously increasing global incidence of diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a cornerstone in type 2 diabetes treatment, demonstrating remarkable efficacy in glycemic control and cardiovascular risk reduction [1, 2]

The gradual dose escalation protocol used in trials helped minimise the severity and duration of these effects, similar to the approach used with currently available treatments

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[15] [18] For borderline results, additional tests such as methylmalonic acid, homocysteine, or holotranscobalamin may be considered