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However, MS therapy has been enriched with a variety of therapeutic approaches to modify the disease course, progression, and control of symptoms (Polman et al., 2006

Here's how small molecules built pharmaceutical empires: Lipitor (atorvastatin) Filed: 1985 | Launched: 1996 Peak sales: $12.9B annually Patent strategy: Multiple filings for different formulations Humira (adalimumab) Filed: 1999 | Launched: 2002 Revenue: $200B+ lifetime Patent wall: 130+ patents filed globally Nexium (esomeprazole) Filed: 1988 | Launched: 2001 Strategy: "Evergreening" from Prilosec Extended monopoly by 6+ years The pattern

Bad News: Tolerability and Dropout Rates One of the biggest drawbacks has been the gastrointestinal distress caused by a GLP-1/glucagon dual agonist

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