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Patients should be monitored for tolerability during dose titration, and bile duct stones remain a rare possibility even without a gallbladder

And the dose equivalencies are not straightforward because you cannot simply convert milligrams between two medications that work through different receptor profiles

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All anti obesity medications including semaglutide, tirzepatide, and liraglutide, may carry gastrointestinal adverse events such as abdominal pain, decreased appetite, and nausea, and they should be used under close medical supervision, particularly in individuals with a family medical history of thyroid cancer, or existing cardiovascular disease, chronic kidney disease, or risk of heart attack

By hitting both pathways at once, tirzepatide produces a more powerful and synergistic effect on appetite suppression and metabolic regulation