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Instead, asparagine supplementation enhances the expression of glutamine synthetase (GLUL) and increases intracellular glutamine usage via glutaminolysis, resulting in the recovery of global protein translation that is blocked by glutamine deprivation 45
The expression of DNMT1 in the striatum and NAc was increased in Fisher 344 rats after acute and repeated METH injections, while the corresponding expression was decreased in Lewis rats 84
Second, the strict administration guidelines can be burdensome
Crucially, a critical assessment of the included literature reveals significant pharmacological limitations, particularly among Level C studies