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Xian M, Wawrzyniak P, Rckert B, Duan S, Meng Y, Sokolowska M, Globinska A, Zhang L, Akdis M, Akdis CA

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While microneedle technology effectively overcomes the stratum corneum barrier, its clinical application remains constrained by low drug-loading capacity and insufficient mechanical strength (Han et al., 2025)

In such cases, no treatment is generally required If required, a surgical excision and complete removal of the macule, primarily to address cosmetic issues may be undertaken Cryotherapy, intense pulsed light (IPL), or laser therapy may be therapeutic Treatment of the underlying associated genetic disorder, if any Follow-up care with regular screening and check-ups are encouraged How can Genital Melanotic Macules be Prevented

That's where IV therapy pulls ahead of the pack