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Mechanism of Action Retatrutide (LY3437943): A first-in-class triple receptor agonist targeting: * GIP receptor * GLP-1 receptor * Glucagon receptor This multimodal activity provides potent appetite suppression, enhanced energy expenditure, and broad metabolic benefits

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The action of GLP-1 not only augments the secretion of insulin from -cells and favors their growth and survival, 302,303 it has been reported that GLP-1 is capable of increasing the mass and functionality of -cells, particularly when those cells are under stress in the milieu of T1D