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Patients experiencing persistent, severe abdominal pain with back radiation, particularly if accompanied by nausea and vomiting, require urgent medical assessment to exclude this serious complication

When the thiol groups of two cysteine residues (as in monomers or constituent units) are brought near each other in the course of protein folding, an oxidation reaction can generate a cystine unit with a disulfide bond (SS)

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The clinics review responses, while formulaic at the start, do attempt to engage with individual patient concerns