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By the time it is visible, the tissue damage is established

However, doctors have become concerned after reports linked it to a rare eye condition that causes sudden and permanent vision loss due to damage to the optic nerve, which is the cable that sends visual information from the eye to the brain

In TGR, and more generally in TrxRs, electron transfer from NADPH to the enzyme is fast and practically irreversible and so an actual ES complex (NADPH-TGR) is not significantly populated during the catalytic cycle 17

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