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McIntyre RS, Alda M, Baldessarini RJ, Bauer M, Berk M, Correll CU, et al

Transgenerational effects of endocrine-disrupting chemicals on male and female reproduction

Investigational oral estrogen receptor antagonist and degraders, such as giredestrant, promote more effective suppression of ER and may be more effective than current endocrine therapies, especially in the presence of ESR1 mutations 7,8,9