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target is at least greater than 7% Overweight/obesity with baseline BMI ideally 25-30% +range Duration of diabetes does not affect parameters, but is usually used in patients when Metformin has proved ineffective/inadequate

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By exploring gut microbiome in subjects characterized by TMAO producer phenotypes, we identified 39 operational taxonomy units that were highly correlated to TMAO productivity, including Emergencia timonensis , which has been recently discovered to convert -butyrobetaine to TMA in vitro