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However, the study design did not allow for the assessment of the effects of semaglutide on bone metabolism, independent of weight loss, as the control group did not experience comparable weight reduction

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By activating both receptors, oxyntomodulin increases energy expenditure, reduces appetite, promotes weight loss, and improves glucose tolerance, showcasing the therapeutic potential of this dual mechanism [79]

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We found that glycolysis, the TCA cycle, and oxidative phosphorylation pathways were all significantly suppressed in our RNA-seq dataset